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Literature summary extracted from

  • Decrem, Y.; Rath, G.; Blasioli, V.; Cauchie, P.; Robert, S.; Beaufays, J.; Frere, J.M.; Feron, O.; Dogne, J.M.; Dessy, C.; Vanhamme, L.; Godfroid, E.
    Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis (2009), J. Exp. Med., 206, 2381-2395.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.21.38 drug development a contact phase inhibitor of FXIIa is an effective and safe antithrombotic agent in vivo Mus musculus
3.4.21.38 drug development a contact phase inhibitor of FXIIa is an effective and safe antithrombotic agent in vivo Homo sapiens
3.4.21.38 drug development a contact phase inhibitor of FXIIa is an effective and safe antithrombotic agent in vivo Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.38 Ir-CPI the recombinant Ixodes ricinus contact phase inhibitor, a Kunitz type protein expressed by the salivary glands of the tick Ixodes ricinus, specifically interacts with activated human contact phase factors FXIIa, FXIa, and kallikrein. Ir-CPI inhibits the activation of contact system factors, and it prolongs the activated partial thromboplastin time in vitro. Effects of Ir-CPI in vivo are determined using both venous and arterial thrombosis models, overview Homo sapiens
3.4.21.38 Ir-CPI the recombinant Ixodes ricinus contact phase inhibitor, a Kunitz-type protein expressed by the salivary glands of the tick Ixodes ricinus, Ir-CPI inhibits the activation of contact system factors, and it prolongs the activated partial thromboplastin time in vitro. Effects of Ir-CPI in vivo are determined using both venous and arterial thrombosis models, overview. the effective antithrombotic dose of Ir-CPI did not promote bleeding or impair blood coagulation parameters Mus musculus
3.4.21.38 Ir-CPI the recombinant Ixodes ricinus contact phase inhibitor, a Kunitz-type protein expressed by the salivary glands of the tick Ixodes ricinus, Ir-CPI inhibits the activation of contact system factors, and it prolongs the activated partial thromboplastin time in vitro. Effects of Ir-CPI in vivo are determined using both venous and arterial thrombosis models, overview. the effective antithrombotic dose of Ir-CPI did not promote bleeding or impair blood coagulation parameters Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.38 extracellular
-
 Mus musculus
-
-
3.4.21.38 extracellular
-
 Homo sapiens
-
-
3.4.21.38 extracellular
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 prekallikrein + H2O Mus musculus
-
 kallikrein + kallikrein prepeptide
-
 ?
3.4.21.38 prekallikrein + H2O Homo sapiens
-
 kallikrein + kallikrein prepeptide
-
 ?
3.4.21.38 prekallikrein + H2O Rattus norvegicus
-
 kallikrein + kallikrein prepeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-
3.4.21.38 Mus musculus
-
-
-
3.4.21.38 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.38 blood
-
 Mus musculus
-
3.4.21.38 blood
-
 Homo sapiens
-
3.4.21.38 blood
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 prekallikrein + H2O
-
 Mus musculus kallikrein + kallikrein prepeptide
-
 ?
3.4.21.38 prekallikrein + H2O
-
 Homo sapiens kallikrein + kallikrein prepeptide
-
 ?
3.4.21.38 prekallikrein + H2O
-
 Rattus norvegicus kallikrein + kallikrein prepeptide
-
 ?
3.4.21.38 prekallikrein + H2O cleavage of a single peptide bond Mus musculus kallikrein + kallikrein prepeptide
-
 ?
3.4.21.38 prekallikrein + H2O cleavage of a single peptide bond Homo sapiens kallikrein + kallikrein prepeptide
-
 ?
3.4.21.38 prekallikrein + H2O cleavage of a single peptide bond Rattus norvegicus kallikrein + kallikrein prepeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 FXIIa
-
 Mus musculus
3.4.21.38 FXIIa
-
 Homo sapiens
3.4.21.38 FXIIa
-
 Rattus norvegicus